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We have also tried 6-4-6-4, but while the distance is shorter, for Asians with not so long arm, to hit 6th position well is also problematic and usually end up sharp.
I once tried moving it down one octave for fun, and found that with T1-4-T1-FD1 (on a Bb-F-Gb-D bass), or T1-FEb1-T1-FEb2 (on a Bb-F-Eb dependent bass) the passage is quite easy with minimal slide movement. The problem is, when move up one octave to the original notes, the middle D does not focus well. It also sounds stuffy. I know I have no open low D to compare, but the low D at FD1 always has snappy intonation and response, at least for me on any horn.
So, what causes this? And is there any way to overcome it? Or should we focus on making 1-4-1-4 work?